A multi-disciplinary team from Ireland’s Trinity College Dublin suggest a “tailored vaccine” could affectively tame bacteria-driven eczema in children. The researchers have identified new cellular targets for a vaccine by furthering their understanding of the immune response in cases of eczema caused by Staphylococcus aureus.

The research team found important “immune signatures” in children with infected eczema flares by examining immune responses among three groups: those with eczema and S. aureus infection, those with eczema without infection, and participants without eczema. They found that T cells and other biomarkers varied significantly between the groups. The immune response was notably suppressed in children with infected flares, impacting vital T cells needed for an effective immune response. The findings provide a basis for developing targeted therapies to relieve recurrent eczema flares. They also highlight the significance of these discoveries and the need for further research to confirm the patterns in larger, more diverse populations.

Reference: Hicks T. A tailored vaccine shows promise in treating childhood eczema. Medical News Today. Published May 8, 2024. Accessed May 29, 2024. https://www.medicalnewstoday.com/articles/a-tailored-vaccine-shows-promise-in-treating-childhood-eczema