In a recent study, researchers highlighted a potential link between early childhood obesity and the development of immune-mediated skin diseases (IMSDs), particularly atopic dermatitis (AD). Researchers analyzed data from over 2 million South Korean children, ages 4 to 12, from 2009 to 2020, examining the impact of body mass index (BMI) on the onset of IMSDs. The study found that obese children (BMI in the 95th percentile or higher) had a 12% higher risk of developing AD, while overweight children (BMI in the 85th to 94th percentile) had a 13% increased risk. Importantly, children who reduced their BMI during the study period also lowered their risk of developing AD, suggesting that weight management may help prevent AD in childhood.

The researchers propose that excess adipose tissue may trigger proinflammatory effects, disrupting skin barrier function and immune balance, though the exact mechanisms remain unclear. They recommend promoting healthy weight maintenance in normal-weight children and encouraging weight loss in overweight or obese children to reduce AD risk.

Reference: Flinn R. Study Links Childhood Obesity to Increased Risk of Atopic Dermatitis. Managed Healthcare Executive. Published September 4, 2024. Accesses September 19, 2024. https://www.managedhealthcareexecutive.com/view/study-links-childhood-obesity-to-increased-risk-of-atopic-dermatitis