The Complex Impact of Diet on Atopic Dermatitis
In a study, researchers analyzed the pathophysiology of atopic dermatitis (AD), which involves genetic and environmental factors, including diet. Maternal dietary restrictions during pregnancy and lactation, as well as the use of hydrolyzed formulas and the delayed introduction of solid foods, have been studied but show no clear beneficial effect in preventing or treating AD. Conversely, exclusive breastfeeding for 3-4 months, diets rich in fruits and vegetables, and prebiotics might offer some benefits. Various dietary interventions have been explored, including eliminating certain foods and supplementing with omega-3 or omega-6 fatty acids, but these strategies have produced inconsistent results.
The Link Between Atopic Dermatitis and Food Allergy: Insights and Prevention Strategies
In a review, researchers explored the intricate relationship between atopic dermatitis (AD) and food allergy, shedding light on recent findings regarding their interconnectedness. AD is recognized as a significant risk factor for the development of food allergy, particularly in infants experiencing skin barrier disruption or persistent AD. However, indiscriminate testing for food triggers is cautioned against, as it may lead to false positives and unnecessary dietary restrictions. Instead, early skincare interventions and targeted treatment strategies, including the introduction of highly allergenic foods, show promise in mitigating the risk of food allergy in children with AD.
The Burden of Atopic Dermatitis: Implications for Healthcare Decision-Makers
Researchers of a review highlighted the often-overlooked burden of atopic dermatitis (AD) in adults, shedding light on its clinical, economic, and humanistic impact. Through a systematic literature review encompassing a wide range of studies, including clinical, economic, and humanistic parameters, the researchers aimed to quantify the comprehensive burden of AD on adults and adolescents from 2011 to 2020.
Study Connects Protein Deficiency to Atopic Dermatitis, Suggests Personalized Treatment Approaches
An Oregon State University study linked a protein deficiency to atopic dermatitis (AD). The research found that mice without COUP-TF interacting protein 2 (Ctip2) showed symptoms like dry skin and inflammation, along with increased levels of TSLP, a protein associated with AD. These findings suggest potential personalized treatments for AD through enhancing Ctip2 expression or adjusting lipid profiles.
Combined Therapy With Dupilumab and Tofacitinib Shows Promise in Severe Atopic Dermatitis
A 35-year-old male with severe atopic dermatitis (AD) saw partial improvement with dupilumab and halobetasol, leading to the addition of the JAK inhibitor tofacitinib. Although this combination cleared his AD, tofacitinib was discontinued due to risks and insurance issues, continuing treatment with only dupilumab. This case emphasizes the importance of risk evaluation and the promise of new JAK inhibitor developments.
