Researchers of recent studies have highlighted the vital role of gut microbiota in the onset of atopic dermatitis (AD). Research underscores the influence of maternal diet and health on fetal development, with microbes in the vaginal tract interacting with the fetus, impacting prenatal growth. Notably, the Stool Microbiome and Allergic ReacTion (SMART) study in China identified delivery mode, feeding method, and intrapartum antibiotic use as significant influencers on the early-life gut microbiome, preceding AD development. Dysbiosis in the gut, particularly in infancy, has been consistently linked to AD, with certain bacterial species associated with increased risk, while short-chain fatty acids show protective effects.

Researchers also highlight the efficacy of probiotics like lactobacillus and bifidobacterium in reducing AD incidence, particularly when administered early in life. Environmental factors, including urban biodiversity and pollutants, also shape the gut microbiome and impact AD development. Clinicians advocate for comprehensive patient education on the gut microbiome’s significance in AD pathogenesis, emphasizing dietary interventions and probiotic supplementation to mitigate disease severity and improve patient outcomes.

Reference: Raglin H. Gut Microbiome Has Significant Impact on Atopic Dermatitis. Dermatology Times. Published October 11, 2023. Accessed February 2, 2024. https://www.dermatologytimes.com/view/gut-microbiome-has-significant-impact-on-atopic-dermatitis