In a video commentary, Karan Lal, DO, MS, explores the link between environmental pollutants and atopic dermatitis (AD) flares, focusing on the AhR pathway’s role in inflammation and itch caused by pollutants. Tapinarof cream, which targets AhR, holds potential for AD treatment, particularly in polluted urban areas. Dr. Lal stresses the need to educate patients about the effects of factors like smoking on AD, as they can activate the AhR pathway, potentially exacerbating the condition.

Reference: Lal K. Pollution and Atopic Dermatitis. The Dermatology Digest. Accessed December 28, 2023. https://thedermdigest.com/video/pollution-and-atopic-dermatitis/